The Volume of Distribution (V_d) of a Drug Is

The volume of distribution (V_d) of a drug is

A) the minimum volume of plasma needed to completely dissolve it
B) the maximum volume of water in a person's body available to dissolve a drug
C) a measure of the solubility as a function of the pH gradient
D) an expression that reflects how a drug distributes once absorbed into the bloodstream
E) None of the above