Which chromatographic instrument is better suited for analysis involving drug molecules with ionizable centers?

Question

Quizplus · Accepted Answer

HPLC/UPLC is better suited for analysis involving drug molecules with ionizable centers because it allows for the use of a wider range of mobile phases and stationary phases, including ion exchange columns, which can effectively separate ionizable compounds. Capillary electrophoresis may also be used for these types of analyses, but it has limitations in terms of sample loading capacity and reproducibility. GC is not suitable for ionizable compounds because they tend to be unstable under the high temperatures required for gas chromatography.

Which Chromatographic Instrument Is Better Suited for Analysis Involving Drug