The toxicology section of a medical examiner's office creates an uncertainty budget for a drug metabolite quantitation as shown below. Why is the contribution for the measurement assurance sample so large?

Question

The toxicology section of a medical examiner's office creates an uncertainty budget for a drug metabolite quantitation as shown below.  Why is the contribution for the measurement assurance sample so large?

Quizplus · Accepted Answer

Measurement assurance samples are designed to capture many contributing factors into one value, including any variations in the extraction process, instrument performance, and analyst technique. Therefore, their contribution to the uncertainty budget is often larger than other sources of uncertainty.

The Toxicology Section of a Medical Examiner's Office Creates an Uncertainty