Chromosomes align at the metaphase plate before separating at anaphase. Which of the following factors keep chromosomes together at metaphase? Please select all that apply.

Question

Quizplus · Accepted Answer

Separase is a protease that cleaves one of the proteins holding sister chromatids together, so is one of the factors that stimulates separation. Securin protein prevents separase from becoming active until the correct time, so helps to stop chromatids separating prematurely. Cohesin holds chromatids together until one of its constituent proteins is cleaved by separase.

Chromosomes Align at the Metaphase Plate Before Separating at Anaphase