APV and the selective GluN2B antagonist ifenprodil enhances the extinction of the fear response.

Question

Quizplus · Accepted Answer

APV is an NMDA receptor antagonist that blocks the activity of these receptors, and while ifenprodil is a selective GluN2B antagonist that can modulate fear responses, the statement that both enhance the extinction of fear response is inaccurate. APV, by blocking NMDA receptors, could interfere with the learning processes necessary for the extinction of fear. Ifenprodil may have complex effects on fear extinction, potentially enhancing it under certain conditions, but the broad statement that both enhance fear extinction is not accurate without specifying the conditions under which this might occur.

APV and the Selective GluN2B Antagonist Ifenprodil Enhances the Extinction