Which of the Following Is the Best Example of a 'Paradigm

Which of the following is the best example of a 'paradigm shift'?

A) when science slowly and progressively rejected the idea that the earth is round
B) normal science
C) the assumption that strange findings reflect broken equipment or a mistake in the analysis
D) the recent switch from the understanding that genes are blueprints to the understanding that genes can be switched on and off
E) falsification of data