Question 1

Drugs undergo various metabolic processes that affect the solubility of the drug. Which of the following enzymatic reactions would most likely result in the least change in water solubility?

Accepted Answer

Hydroxylation results in the addition of a hydroxyl (-OH) group and generally has little effect on drug solubility. Glucuronidation, the addition of highly water soluble glucuronic acid, increases water solubility significantly. Sulphonation also increases water solubility, whereas cyclization decreases water solubility.

Question 2

Which of the following drugs is not an MAOI (Mono Amine Oxidase Inhibitor)?

Accepted Answer

Of the choices given, all are MAOIs except Citalopram, which is a Selective Serotonin Reuptake Inhibitor (SSRI).

Question 3

Which of the following drugs is a sulfonylurea?

Accepted Answer

Glipizide (Glucotrol) is a hypoglycemic agent in the sulfonylurea class and is indicated for Type II Diabetes. Olmesartan (Benicar) is an angiotensin II receptor antagonist used in treating hypertension. Piroxicam(Feldene) is an NSAID useful in inflammatory disorders. Sirolimus (Rapamune) is a lactone used as an immunosuppressant in transplant patients.

Question 4

Cholestyramine should be taken with which of the following?

Accepted Answer

Cholestyramine is water soluble and may be taken with food. It should not be mixed with any carbonated beverage, as this decreases absorption.

Question 5

What is the best way for a bisphosphonate to be taken?

Accepted Answer

Bisphosphonates are best absorbed on an empty stomach with a large amount of water to minimize gastrointestinal upset and esophageal irritation.

Question 6

When using which of the following creams should intercourse be avoided because the cream reduces contraceptive effectiveness?

Accepted Answer

Clindamycin is the only one of the listed creams that is known to reduce the effectiveness of diaphragms and condoms, thereby decreasing the effectiveness of these birth control approaches.

Question 7

Zolpidem (Ambien) should be used for:

Accepted Answer

Ambien is recommended only for short term use on the order of 7-10 days because of a risk of physical and psychological dependence.

Question 8

A patient calls and asks if they can bring in one of their vitamin solutions because it has lost its label. You are told that the solution is light red or pink. Which is the most likely vitamin in that solution?

Accepted Answer

Vitamin B₁₂in solution has a pink color. The others are colorless.

Question 9

The FDA (Food and Drug Administration) has approved the use of decongestants for which of the following conditions?

Accepted Answer

Decongestants are only approved by the FDA for allergic rhinitis and the common cold. Decongestants are not approved for sinusitis. Decongestants should not be used for children under 2 years of age.

Question 10

Which of the following fentanyl preparations is used for chronic pain?

Accepted Answer

Duragesic is the only one of the listed drugs used for chronic pain management. Fentora and Actiq are used for breakthrough pain in cancer patients tolerant to opioids.

Question 11

Which of the following vitamins can turn urine a bright yellow?

Accepted Answer

Vitamin B₂ can turn urine a bright yellow color.

Question 12

Which of the following vitamins are water soluble and are excreted in the urine? I. Vitamin C II. Vitamin B₁₂ III. Vitamin D IV. Vitamin E

Accepted Answer

Vitamins C and the B-complex vitamins are water soluble. Vitamins A, D, E, and K are fat soluble vitamins.

Question 13

Which of the following has a "Black Box Warning" associated with it?

Accepted Answer

Nadolol, a non-selective beta blocker, carries a Black Box Warning-abrupt cessation of Nadolol must be avoided due to the risk of exacerbation of severe angina, myocardial infarction (MI), and ventricular arrhythmias. None of the other drugs carries a Black Box Warning. Namenda is an NMDA receptor antagonist. Dronabinol is a cannabinoid agonist. Propofol is a hypnotic.

Question 14

Which of the following warnings should be listed on a prescription for tetracycline?

Accepted Answer

Tetracycline has known photosensitivity reactions. It should not be taken with any milk or dairy products, antacids, or laxatives and no drug should be taken within 1 hour of alcohol ingestion.

Question 15

Of the following drugs, which are considered positive inotropes?
I. Digoxin
II. Dopamine
III. Dobutamine

Accepted Answer

Positively inotropic agents increase the strength of muscular contractions in the heart. All three agents listed are positive inotropes.

Question 16

A patient using nitroglycerin approaches you asking what possible side effects there might be. What could you tell him?
I. Arrhythmias
II. Headache
III. Syncope

Accepted Answer

Nitroglycerin suppresses cardiac contractility, inhibits coronary artery spasm, and reduces the frequency and severity of angina attacks. Arrhythmias are not a side effect of nitroglycerin use, but headache and syncope can be side effects.

Question 17

What is the most common and most serious adverse effect of clindamycin?
I. Pseudomembranous colitis
II. Neutropenia
III. Hematuria

Accepted Answer

Pseudomembranous colitis is a classic and serious adverse effect of clindamycin use. Neutropenia is a possible adverse effect, but is not generally considered as serious or life-threatening as Pseudomembranous colitis. Hematuria, blood in the urine, is not considered a side effect of clindamycin use.

Question 18

A patient is on lovastatin. What is the biochemical pathway that is inhibited by this drug?

Accepted Answer

Lovastatin is an HMG-CoA reductase inhibitor. HMG-CoA reductase is the rate-limiting enzyme of the mevalonate (isoprenoid) pathway of cholesterol synthesis.

Question 19

Ketoprofen is used to treat _______ and is contraindicated with/in ___________.

Accepted Answer

Ketoprofen is an NSAID (non-steroidal anti-inflammatory agent) and is used to treat pain and inflammation. Ketoprofen is contraindicated in peptic ulcer disease.

Question 20

Colchicine is used to treat _______ and is contraindicated with/in ___________.

Accepted Answer

Colchicine is an anti-gout drug that reduces uric acid deposition in joints. It has both chronic and acute usage. Blood dyscrasias are a contraindication for the use of colchicine because dyscrasias are a possible adverse effect of colchicine use.

Quiz 3: Pharmaceutical

Drugs undergo various metabolic processes that affect the solubility of the drug. Which of the following enzymatic reactions would most likely result in the least change in water solubility?

Which of the following drugs is not an MAOI (Mono Amine Oxidase Inhibitor) ?

Which of the following drugs is a sulfonylurea?

Cholestyramine should be taken with which of the following?

What is the best way for a bisphosphonate to be taken?

When using which of the following creams should intercourse be avoided because the cream reduces contraceptive effectiveness?

Zolpidem (Ambien) should be used for:

A patient calls and asks if they can bring in one of their vitamin solutions because it has lost its label. You are told that the solution is light red or pink. Which is the most likely vitamin in that solution?

The FDA (Food and Drug Administration) has approved the use of decongestants for which of the following conditions?

Which of the following fentanyl preparations is used for chronic pain?

Which of the following vitamins can turn urine a bright yellow?

Which of the following vitamins are water soluble and are excreted in the urine? I. Vitamin C II. Vitamin B₁₂ III. Vitamin D IV. Vitamin E

Which of the following has a "Black Box Warning" associated with it?

Which of the following warnings should be listed on a prescription for tetracycline?

Of the following drugs, which are considered positive inotropes? I. Digoxin II. Dopamine III. Dobutamine

A patient using nitroglycerin approaches you asking what possible side effects there might be. What could you tell him? I. Arrhythmias II. Headache III. Syncope

What is the most common and most serious adverse effect of clindamycin? I. Pseudomembranous colitis II. Neutropenia III. Hematuria

A patient is on lovastatin. What is the biochemical pathway that is inhibited by this drug?

Ketoprofen is used to treat _ and is contraindicated with/in _____.

Colchicine is used to treat _ and is contraindicated with/in _____.

Quiz 3: Pharmaceutical

Drugs undergo various metabolic processes that affect the solubility of the drug. Which of the following enzymatic reactions would most likely result in the least change in water solubility?

Which of the following drugs is not an MAOI (Mono Amine Oxidase Inhibitor) ?

Which of the following drugs is a sulfonylurea?

Cholestyramine should be taken with which of the following?

What is the best way for a bisphosphonate to be taken?

When using which of the following creams should intercourse be avoided because the cream reduces contraceptive effectiveness?

Zolpidem (Ambien) should be used for:

A patient calls and asks if they can bring in one of their vitamin solutions because it has lost its label. You are told that the solution is light red or pink. Which is the most likely vitamin in that solution?

The FDA (Food and Drug Administration) has approved the use of decongestants for which of the following conditions?

Which of the following fentanyl preparations is used for chronic pain?

Which of the following vitamins can turn urine a bright yellow?

Which of the following vitamins are water soluble and are excreted in the urine? I. Vitamin C II. Vitamin B12 III. Vitamin D IV. Vitamin E

Which of the following has a "Black Box Warning" associated with it?

Which of the following warnings should be listed on a prescription for tetracycline?

Of the following drugs, which are considered positive inotropes? I. Digoxin II. Dopamine III. Dobutamine

A patient using nitroglycerin approaches you asking what possible side effects there might be. What could you tell him? I. Arrhythmias II. Headache III. Syncope

What is the most common and most serious adverse effect of clindamycin? I. Pseudomembranous colitis II. Neutropenia III. Hematuria

A patient is on lovastatin. What is the biochemical pathway that is inhibited by this drug?

Ketoprofen is used to treat _______ and is contraindicated with/in ___________.

Colchicine is used to treat _______ and is contraindicated with/in ___________.

Which of the following vitamins are water soluble and are excreted in the urine? I. Vitamin C II. Vitamin B₁₂ III. Vitamin D IV. Vitamin E

Ketoprofen is used to treat _ and is contraindicated with/in _____.

Colchicine is used to treat _ and is contraindicated with/in _____.