A drug's effectiveness is influenced by its metabolism and biotransformation. Some drugs are less effective because of the "Patient-pass" effect. Which route of drug administration is influenced by this effect?
A) Oral
B) Subcutaneous
C) Intramuscular
D) Intravenous

Question

Quizplus · Accepted Answer

Most metabolism or biotransformation occurs in the liver. The first-pass effect
occurs with medications taken by mouth (enteral route). After ingestion, the drug is absorbed by the gastrointestinal system and then first passes through the liver, where some of the drug may be metabolized. Thus, the drug may not be as effective as it continues through the pharmacokinetic phases. The parenteral route (subcutaneous, IM, IV) bypasses the first-pass effect, so more of the drug is available to the body tissues and cells.

A Drug's Effectiveness Is Influenced by Its Metabolism and Biotransformation