The Great Pestilence, which occurred in the year 1576, was an unknown illness characterized by high fevers and bleeding. The disease caused millions of deaths in Mexico, resulting in the collapse of some Indigenous populations. This disease would be described as

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An epidemic refers to a widespread occurrence of an infectious disease in a community at a particular time, which fits the description of the Great Pestilence in Mexico.

The Great Pestilence, Which Occurred in the Year 1576, Was