A strain of mice engineered with a third copy of a critical chromosome 21 region produced ______.

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This strain of mice, engineered to carry an extra copy of a critical region on chromosome 21, produced less of two proteins that are crucial for neural survival, which is a characteristic associated with Down syndrome in humans. This genetic modification is aimed at studying the effects of gene dosage on neural development and function, as chromosome 21 is the chromosome implicated in Down syndrome.

A Strain of Mice Engineered with a Third Copy of a Critical