Sickle-cell anemia is a disease that occurred from a point mutation in the replication of DNA. That mutation causes a change of an amino acid in b-globulin. Nonrandom mating (not mating with any individual that has the allele for the mutation) could result in the removal of the mutated allele from a population. This would be an example of natural selection.

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This scenario describes genetic drift or possibly assortative mating rather than natural selection. Natural selection involves differential survival and reproduction of individuals due to differences in phenotype, while the removal of a mutated allele through nonrandom mating does not necessarily involve these elements.

Sickle-Cell Anemia Is a Disease That Occurred from a Point