Although Inbreeding by Itself Does Not Affect Allele Frequencies, How

Although inbreeding by itself does not affect allele frequencies, how might inbreeding indirectly affect allele frequencies over the course of many generations if natural selection was also occurring?

A) Inbreeding favors homozygotes. If a homozygote has a higher Darwinian fitness, inbreeding would accelerate the prevalence of the allele in the population. If a homozygote has a lower fitness, inbreeding would accelerate the elimination of the allele from the population.
B) Inbreeding favors homozygotes. If a homozygote has a lower Darwinian fitness, inbreeding would accelerate the prevalence of the allele in the population. If a homozygote has a higher fitness, inbreeding would accelerate the elimination of the allele from the population.
C) Inbreeding never occurs in a natural population, therefore the fitness and allele frequencies would not be affected.
D) None of these choices are correct.