The amine group of the amino acid monomers used in SPPS can be protected by a ____________.
I. phosphate group
II. tert-butoxycarbonyl group (t-Boc)
III. fluoprenylmethyloxycarbonyl group (Fmoc)
IV. sulfonamide group

Question

Quizplus · Accepted Answer

The tert-butoxycarbonyl group (t-Boc) and the fluorenylmethyloxycarbonyl group (Fmoc) are commonly used to protect the amine group of amino acids in solid-phase peptide synthesis (SPPS) to prevent unwanted reactions.

The Amine Group of the Amino Acid Monomers Used in SPPS