Which of the following correctly ranks the steps in the secretory pathway?
1) Ligand (hormone) binds to receptor.
2) Activated adenylate cyclase produces cAMP from ATP.
3) G protein ? subunit exchanges bound GDP for GTP.
4) cAMP binds to the regulatory subunits of PKA, activating it.
5) G? subunit dissociates from complex and activates adenylate cyclase.
6) Active PKA subunits phosphorylate targets in the cell, regulating function.
7) The catalytic subunits of PKA dissociate.

Question

Quizplus · Accepted Answer

The correct sequence starts with the ligand binding to the receptor (1), followed by the G protein alpha subunit exchanging GDP for GTP (3), leading to the dissociation of the Gα subunit from the complex and activation of adenylate cyclase (5). This enzyme then converts ATP to cAMP (2), which binds to the regulatory subunits of PKA, activating it (4). Finally, the catalytic subunits of PKA dissociate (7) and phosphorylate targets in the cell, regulating its function (6).

Which of the Following Correctly Ranks the Steps in the Secretory