Which of the following laboratory results best represents a patient with Paget's disease?
A) Decreased urinary hydroxyproline and increased serum alkaline phosphatase
B) Increased urinary hydroxyproline and decreased serum alkaline phosphatase
C) Normal urinary hydroxyproline and normal serum alkaline phosphatase
D) Decreased urinary hydroxyproline and decreased serum alkaline phosphatase

Question

Quizplus · Accepted Answer

Paget's disease of bone is characterized by an increase in bone remodeling, leading to increased serum alkaline phosphatase, a marker of bone formation. Increased urinary hydroxyproline, a breakdown product of collagen, reflects increased bone resorption. Therefore, the combination of increased serum alkaline phosphatase and decreased urinary hydroxyproline does not match the typical laboratory findings in Paget's disease.

Which of the Following Laboratory Results Best Represents a Patient