Which Statement Is True Concerning a Negative Catalyst (Inhibitor)

Which statement is true concerning a negative catalyst (inhibitor) ?

A) It lowers the energy of activation of the rate determining step.
B) It increases the heat of reaction.
C) It never undergoes a chemical change at any time during a chemical reaction.
D) It blocks the path with the highest energy of activation for the rate determining step.
E) It blocks the path with the lowest energy of activation for the rate determining step.