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Which of the Following Is Observed in the Mechanism of Citrate

Question 4

Multiple Choice

Which of the following is observed in the mechanism of citrate synthase?


A) a histidine residue acts as a base, deprotonating oxaloacetate
B) an aspartic acid residue acts as a base, deprotonating oxaloacetate
C) a histidine residue hydrogen bonds with the carbonyl oxygen of oxaloacetate to enable a nucleophilic attack
D) removal of the CoA is accomplished by transfer to a serine residue, then hydrolysis
E) all of the above

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