If acetyl-CoA labeled on the methyl carbon were used as the substrate for the citric acid cycle, where would the labeled carbon appear in oxaloacetate produced from one round of the cycle?

Question

Quizplus · Accepted Answer

The methyl carbon of acetyl-CoA becomes part of the citrate molecule, which is then converted through the cycle. By the time oxaloacetate is regenerated, the labeled carbon can appear at either C2 or C3 due to the symmetrical nature of the intermediates and the reactions involved.

If Acetyl-CoA Labeled on the Methyl Carbon Were Used as the Substrate