A 35-Year-Old Woman Presents with Weakness and Spasticity in the Lower

A 35-year-old woman presents with weakness and spasticity in the lower left extremity, visual impairment and throbbing in the left eye, and difficulties with balance, fatigue, and malaise. There is an increase in CSF protein, elevated gamma globulin, and moderate pleocytosis. MRI confirms areas of demyelination in the anterior corpus callosum. Imaging identifies plaques that are hyperintense on T2-weighted and fluid attenuated inversion recovery (FLAIR) images, and hypointense on T1-weighted scans. Which of the following cells are specifically targeted in her condition?

A) Microglia
B) Oligodendrocytes
C) Astrocytes
D) Schwann cells
E) Multipolar neurons