A 2-year-old boy presents with hearing impairment, poliosis (a white shock of hair), complete heterochromia and sectoral heterochromia, hypertelorism, a low hairline with eyebrows that touch in the middle, white pigmentation of the skin, and suspected neurologic deficits. He is diagnosed with Waardenburg syndrome with a mutation in the PAX-3 gene that affects neural crest differentiation. Which of the following structures would most likely also be affected in this patient?

Question

Quizplus · Accepted Answer

Neurons and satellite cells of the spinal ganglion are derived from neural crest cells, which are affected in Waardenburg syndrome due to the PAX-3 gene mutation.

A 2-Year-Old Boy Presents with Hearing Impairment, Poliosis (A White