A 16-year-old, seemingly normal female is diagnosed with androgen insensitivity disorder. She has never had a menstrual cycle and is found to have a blind-ending vagina; no uterus, cervix, or ovaries; a $46 \mathrm{XY}$ genotype; and intra-abdominal testes. Her serum testosterone is elevated. Which of the following characteristics is caused by lack of androgen receptors?

Question

Quizplus · Accepted Answer

[IX C]. The elevated serum testosterone is due to lack of androgen receptors on the anterior pituitary (which normally would mediate negative feedback by testosterone). The presence of testes is due to the male genotype. The lack of uterus and cervix is due to anti-müllerian hormone (secreted by the fetal testes), which suppressed differentiation of the müllerian ducts into the internal female genital tract. The lack of menstrual cycles is due to the absence of a female reproductive tract.

A 16-Year-Old, Seemingly Normal Female Is Diagnosed with Androgen Insensitivity 46XY46 \mathrm{XY}46XY

A 16-Year-Old, Seemingly Normal Female Is Diagnosed with Androgen Insensitivity $46 \mathrm{XY}$