When orally administered drugs proceed directly to the liver to be metabolized prior to being distributed throughout the body, this is called:

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The first-pass effect refers to the process where orally administered drugs are absorbed through the gastrointestinal tract and then transported directly to the liver via the hepatic portal vein, where they are metabolized before reaching the systemic circulation. This can significantly reduce the bioavailability of the drug.

When Orally Administered Drugs Proceed Directly to the Liver to Be