Drugs Such as Ramipril, Losartan, and Codeine Are Called Prodrugs

Drugs such as ramipril, losartan, and codeine are called prodrugs because they:

A) Require the liver to metabolize the drug in order to make it inactive
B) Require enterohepatic recirculation in order to be active
C) Need other drugs to be taken at the same time to "turn them on" and make them active
D) Require metabolism in order to become active in the body