Aerobic Respiration Is Ultimately the Reaction of Glucose with Oxygen

Aerobic respiration is ultimately the reaction of glucose with oxygen to generate carbon dioxide, water, and energy. However, in a cell this process involves the transfer of electrons from glucose to carriers such as NAD⁺ over a lengthy series of steps. Why don't cells employ the direct reaction of glucose with oxygen to generate energy?

A) The direct reaction of oxygen with glucose would be much less efficient.
B) The direct reaction of oxygen with glucose does not spontaneously occur.
C) Oxygen and glucose are localized in different subcellular compartments.
D) The direct transfer of electrons from glucose to oxygen occurs via a combustion reaction that is incompatible with life.