Pemphigus vulgaris is an autoimmune disorder in which antibodies are produced against the cadherins of desmosomes.The blistering seen in these individuals is probably a result of
A)a decrease in flexibility of the cell membrane.
B)inadequate numbers of G-protein receptors.
C)inadequate production of cytoskeletal proteins.
D)loss of cell-cell adhesion.

Question

Quizplus · Accepted Answer

Pemphigus vulgaris is an autoimmune disorder that results in the production of antibodies against cadherins of desmosomes. These antibodies attack the desmosomes, which are responsible for cell-cell adhesion in epithelial tissue. Loss of cell-cell adhesion leads to the separation of the epithelial cells, causing blistering seen in affected individuals.

Pemphigus Vulgaris Is an Autoimmune Disorder in Which Antibodies Are