A diathesis-stress model of depression suggests that it is most likely to occur when those who have a pessimistic outlook encounter significant negative life events.

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The diathesis-stress model posits that depression (and other psychological disorders) results from the interaction between a pre-existing vulnerability (diathesis) and stressful life events. A pessimistic outlook can be considered a vulnerability that, when combined with significant negative life events, increases the likelihood of developing depression.

A Diathesis-Stress Model of Depression Suggests That It Is Most