You are studying the effects of the addition of a novel compound to the chow of laboratory animals on the overall rate of flux through glycolysis in skeletal muscle. You discover that when the animals consume the compound containing chow, there is a decrease in glycolytic flux to pyruvate while at the same time there is increased glucose output to the blood. Cells isolated from muscle biopsy tissue from these animals respond to addition of the compound with a dramatic rise in the levels of cAMP. Given this effect of the compound, which of the following will occur first?

Question

Quizplus · Accepted Answer

The compound increases cAMP levels, which will first bind to the regulatory subunits of PKA.  The primary function of cAMP is to bind to the regulatory subunits of PKA, which leads to the release of the catalytic subunits.

You Are Studying the Effects of the Addition of a Novel