You are studying the effects of the addition of a novel compound to the chow of laboratory animals on the overall rate of flux through glycolysis. You discover that when the animals consume the compound containing chow, there is an increase in glycolytic flux to pyruvate. Examination of cells from the livers of these animals demonstrates that when the compound enters the cells, it causes a rapid decrease in the ATP:ADP ratio. This effect most likely results in which of the following?

Question

Quizplus · Accepted Answer

A decrease in the ATP:ADP ratio indicates a higher demand for ATP, which stimulates glycolysis to produce more ATP. This results in increased activity of phosphofructokinase-1, a key regulatory enzyme in glycolysis, thereby increasing the glycolytic pathway flux to meet the energy demand.  As the level of ATP falls, the level of ADP and AMP will increase. AMP serves as an allosteric activator of the rate-limiting enzyme of glycolysis, PFK1. Thus, as the level of ATP falls, the rate of flux through glycolysis will increase.

You Are Studying the Effects of the Addition of a Novel