An increase in the state of phosphorylation, in hepatocytes in response to glucagon action, will be most accurately reflected by which of the following statements?

Question

Quizplus · Accepted Answer

Glucagon activates phosphorylation cascades in hepatocytes, leading to increased glycogen phosphorylase activity to promote glycogen breakdown. When glucagon binds to its receptors on hepatocytes, there is activation of adenylate cyclase resulting in increased cAMP with consequent activation of PKA. PKA phosphorylates and activates glycogen synthase-phosphorylase kinase, which will phosphorylate and activate phosphorylase while also phosphorylating and inhibiting glycogen synthase.

An Increase in the State of Phosphorylation, in Hepatocytes in Response