Ethanol metabolism is associated with a disruption in the NADH:NAD+ ratio. Which of the following is one major consequence of this
Disruption?

Question

Quizplus · Accepted Answer

The increased NADH:NAD+ ratio from ethanol metabolism leads to an increase in glycerol 3-phosphate, which contributes to triglyceride production and can result in fatty liver.  The altered NADH:NAD+ ratio that in turn inhibits gluconeogenesis, inhibits fatty acid oxidation and the activity of the TCA cycle. The reduction in NAD+ impairs the flux of glucose through glycolysis at the glyceraldehyde-3-phosphate dehydrogenase reaction, thereby limiting energy production. The reduction in cytosolic NAD+ leads to reduced activity of glycerol- 3-phosphate dehydrogenase (in the glycerol 3-phosphate to DHAP direction), resulting in increased levels of glycerol 3-phosphate which is the backbone for the synthesis of the triglycerides. Both of these 2 events lead to fatty acid deposition in the liver leading to fatty liver syndrome and excessive levels of lipids in the blood, referred to as hyperlipidemia.

Ethanol Metabolism Is Associated with a Disruption in the NADH:NAD