Lipoxygenase converts arachidonic acid to biologically active compounds called leukotrienes. Leukotrienes have been implicated in several disease entities, including allergic asthma, where they are presumed to mediate bronchoconstriction. Introducing leukotrienes into an airway would be expected to cause which of the following responses?

Question

Quizplus · Accepted Answer

Bronchiole volume contributes to dead space volume, so increasing bronchoconstriction would decrease bronchiolar volume and thus decrease dead space volume. Bronchoconstriction is a major determinant of airway resistance to air flow.

Lipoxygenase Converts Arachidonic Acid to Biologically Active Compounds Called Leukotrienes