You are studying the effects of serum lipoproteins, of the HDL type, on the migration of endothelial cells in culture. Whereas, in one preparation of HDL from wild-type mice you observe significant increases in cell migration, a preparation from a mutant mouse line shows no increase in migration. Knowing the effects of HDL-associated lipids, which of the following lipid classes is most likely to be missing from the mutant mouse HDL preparation?

Question

Quizplus · Accepted Answer

Sphingosine-1-phosphate (S1P) is known to be associated with HDL and plays a significant role in promoting endothelial cell migration. Its absence in the mutant mouse HDL preparation could explain the lack of increased cell migration.

You Are Studying the Effects of Serum Lipoproteins, of the HDL