The Ability of the Liver to Regulate the Level of Blood

The ability of the liver to regulate the level of blood glucose is critical for survival. A number of sources of carbon atoms of nonhepatic origin are used by the liver for gluconeogenesis. However, the net conversion of carbons from fat into carbons of glucose cannot occur in humans because of which of the following?

A) fat oxidation occurs in the mitochondria and gluconeogenesis occurs in the cytosol
B) states of catabolism and anabolism are never concurrently active
C) storage of fats occurs in adipose tissue and gluconeogenesis occurs in liver and kidney
D) the carbons of acetyl-CoA from fat oxidation are lost as CO₂ in the TCA cycle
E) the carbons of acetyl-CoA from fat oxidation inhibit conversion of pyruvate to oxaloacetate