You have generated a line of transgenic mice in which the gene encoding the transcription factor, small heterodimer partner (SHP) has been disabled specifically in hepatocytes. Which of the following genes, involved in bile acid metabolism, would most likely exhibit unregulated expression in the livers of these mice?
A) bile salt export protein (BSEP)
B) farnesoid X receptor (FXR)
C) 3β-hydroxy-Δ5 C-27-steroid oxidoreductase (HSD3B7)
D) 7α-hydroxylase (CYP7A1)
E) multidrug-resistance-associated protein 2 (MRP2)
Correct Answer:
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