The Ayurvedic practice of medicine, native to India, has demonstrated a cholesterol-lowering benefit to the guggul lipid extract from the myrrh tree, guggulsterone. This lipid extract has been shown in laboratory studies to activate the expression of a gene involved in the regulation of bile acid metabolism. Which of the following genes is activated by guggul lipids?
A) 7a-hydroxylase (CYP7A1)
B) farnesoid X receptor (FXR)
C) pregnane X receptor (PXR)
D) multidrug-resistance protein 3 (MDR3)
E) small heterodimer partner (SHP)
Correct Answer:
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