Some types of malignant cells lack expression of fibronectin. The loss of fibronectin by these cells would most likely be associated with which of the following?

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Quizplus · Accepted Answer

Fibronectin is an extracellular matrix protein that binds to integrins, facilitating cell adhesion. Loss of fibronectin would reduce integrin-mediated cell adhesion. Fibronectin is an ECM glycoprotein that is responsible for interaction with integrins present in the plasma membrane of cells, as well as interactions with collagens and glycosaminoglycans. The loss of functional fibronectin would result in inappropriate intracellular signaling, cell shape changes, and cell movements.

Some Types of Malignant Cells Lack Expression of Fibronectin