A 63-year-old man is being seen by his physician as a follow-up to gastric surgery for the treatment of a severe duodenal ulcers. This patient has the ulcers removed by surgical resection of the proximal portion of the duodenum to the distal end of the corpus of the stomach. The patient has been prescribed a proton pump inhibitor (PPI) because the surgery required removal of the region of the stomach that contains cells involved in the negative regulation of acid secretion. Which of the following represents these antrum located cells?

Question

Quizplus · Accepted Answer

D cells in the antrum of the stomach secrete somatostatin, which negatively regulates acid secretion by inhibiting the release of gastrin from G cells and histamine from ECL cells. The antrum of the stomach is also referred to as the pyloric gland area. The pyloric glands contain cells that secrete gastrin (G cells) and somatostatin (D cells). Somatostatin exerts a tonic paracrine inhibition of gastrin secretion from G cells, thereby controlling overall gastric acid secretion by parietal cells of the fundus and corpus of the stomach. Somatostatin can also interfere with gastric acid secretion exerted by the action of histamine. Somatostatin blocks histamine release from enterochromaffin-like cells (ECL) in the gastric mucosa.

A 63-Year-Old Man Is Being Seen by His Physician as a Follow-Up