The gut peptide ghrelin is posttranslationally modified before it is fully active. Which of the following represents the type of modification that is necessary for its biological action?

Question

Quizplus · Accepted Answer

Ghrelin requires acylation, specifically octanoylation, for its biological activity, which allows it to bind to its receptor and exert its effects. Bioactive ghrelin is acylated on the serine at position 3 with n-octanoic acid. The attachment of octanoic acid to Ser3 of ghrelin is accomplished by the acyltransferase identified as ghrelin O-acyltransferase (GOAT; also referred to as membrane-bound O-acyltransferase domain-containing 4, MBOAT4).

The Gut Peptide Ghrelin Is Posttranslationally Modified Before It Is