Several gut-derived factors control feeding behaviors elicited by the brain. Most of these factors exert their effects by reducing the desire for food intake. The synthesis of one of these factors is stimulated by fat intake and inhibited by leptin release from adipose tissue. In addition, vagal efferents are not required for release but the activity of another gut factor is involved in its release. Which one of the following factors fits each of these statements?

Question

Quizplus · Accepted Answer

Apolipoprotein A-IV (apoA-IV) synthesis is stimulated by fat intake and inhibited by leptin. It does not require vagal efferents for release, but its release is influenced by other gut factors. Apolipoprotein A-IV (apoA-IV) is synthesized exclusively in the small intestine and the hypothalamus. Intestinal synthesis of apoA-IV increases in response to ingestion and absorption of fat and it is subsequently incorporated into chylomicrons and delivered to the circulation via the lymphatic system. Systemic apoA-IV exerts effects in the CNS involving the sensation of satiety.

Several Gut-Derived Factors Control Feeding Behaviors Elicited by the Brain