Type 1 diabetes is most often characterized by which of the following?

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Type 1 diabetes is characterized by the autoimmune destruction of insulin-producing beta cells in the pancreas, leading to insufficient insulin production. This results in elevated fatty acid oxidation and ketone body production, causing ketonemia.  The most frequent consequence of poorly controlled T1D is ketoacidosis, referred to as diabetic ketoacidosis, DKA. The hyperketonemia in DKA is the result of insulin deficiency and unregulated glucagon secretion from a-cells of the pancreas. Circulating glucagon stimulates the adipose tissue to release fatty acids which are taken up and oxidized, primarily by the liver. Under these conditions, the level of fatty acid oxidation is in excess of the livers' ability to fully oxidize the excess acetyl-CoA and, thus, the compound is diverted into ketones synthesis. The ketones are released into the circulation and because they are acidic lower the pH of the blood resulting in metabolic acidosis.

Type 1 Diabetes Is Most Often Characterized by Which of the Following