You are the physician treating a 14-year-old adolescent girl who has been poorly controlling her Type 1 diabetes. Blood analysis indicates that she has increased levels of hemoglobin A1c. Which of the following best explains this increase?
A) glucose competes with other sugars for glycosylation of hemoglobin
B) hemoglobin is glycosylated in erythrocyte Golgi complexes
C) hemoglobin is nonenzymatically glycosylated when serum glucose concentrations are increased
D) an increased serum glucose concentration inhibits erythrocyte degradation by spleen cells
E) an increased serum glucose concentration inhibits lysosomal degradation of hemoglobin
Correct Answer:
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