You Are Carrying Out a Routine Follow-Up Examination a 59-Year-Old

You are carrying out a routine follow-up examination a 59-year-old asymptomatic man. He jogs a
Little bit everyday and plays golf. His LDL in the
Past was 177 mg/dL. He has a history of hypertension, and there is a history of premature heart disease in his family. A stress test is normal to stage
6) He is on a statin, an antihypertensive, and lowdose aspirin. Physical examination demonstrates he is 6 ft 2 in tall and weighs 220 lb with a waist circumference of 41 in and his BMI is 28 kg/m2. His blood pressure, on this treatment, is 150/88 mm Hg; his cholesterol is 220 mg/dL, LDL is 140 mg/dL, HDL is 36 mg/dL, triglycerides are 220 mg/dL, and his fasting blood glucose is 120 mg/ dL. Because he is doing so well, he stops his statin and low-dose aspirin. Decreased activity in which of the following would be apparent in this patient given his change in medication?

A) adiponectin
B) monocyte chemotactic protein-1, MCP-1
C) nitric oxide synthase, NOS
D) plasminogen activator inhibitor-1, PAI-1
E) prostaglandin E₂, PGE₂