In G proteins,binding of GTP causes Gₐ dissociation.Which of the following effector proteins does it subsequently associate with?
A)adenylyl cyclase
B)GTPase
C)cAMP
D)Gγ

Question

Quizplus · Accepted Answer

When Gα dissociates from the Gβγ complex upon binding GTP, it can subsequently associate with adenylyl cyclase and activate the production of cAMP. Therefore, choice A (adenylyl cyclase) is the best answer. Choice B (GTPase) is not correct because GTPase is an enzyme that catalyzes the hydrolysis of GTP to GDP, which is already a function of the Gα subunit. Choice C (cAMP) is not correct because cAMP is the second messenger produced by the activated adenylyl cyclase, and not directly associated with the Gα subunit. Choice D (Gγ) is not correct because Gγ remains associated with Gβ upon dissociation from Gα.

In G Proteins,binding of GTP Causes Gₐ Dissociation