Which of the following is the proposed mechanism of aspartate protease catalysis?
A)covalent nucleophilic
B)covalent electrophilic facilitated by a low-barrier hydrogen bond
C)specific base catalysis
D)general base-general acid facilitated by a low-barrier hydrogen bond

Question

Quizplus · Accepted Answer

Aspartate protease catalysis is proposed to operate through a general base-general acid mechanism facilitated by a low-barrier hydrogen bond. This involves the aspartate residues acting alternately as a general base and general acid to catalyze the hydrolysis of peptide bonds.

Which of the Following Is the Proposed Mechanism of Aspartate