Which research finding does not confirm a role for serotonin dysfunction in mood disorders?

Question

Quizplus · Accepted Answer

Decreased numbers of postsynaptic 5-HT receptors (specifically, the typo "5-HT₂" seems to be an error and should likely refer to a subtype of 5-HT receptors) would suggest an alteration in serotonin receptor availability, which is consistent with serotonin dysfunction theories in mood disorders. However, the correct answer to the question asking for a finding that does not confirm a role for serotonin dysfunction would not involve direct evidence of altered serotonin receptor numbers or function. Choices B, C, and D all provide evidence supporting a role for serotonin dysfunction in mood disorders: B) Low 5-HIAA turnover indicates reduced serotonin metabolism, consistent with dysfunction. C) Rapid tryptophan depletion leading to symptom relapse in depressed patients suggests that reduced serotonin availability can worsen mood, supporting its role in mood regulation. D) Altered sensitivity of 5-HT receptors in depressed individuals suggests a dysfunction in the serotonin system. Therefore, none of these findings disconfirms a role for serotonin dysfunction in mood disorders, making A the incorrect choice in the context of the question's intent.

Which Research Finding Does Not Confirm a Role for Serotonin