Hydrogen is often abstracted from substrates as H⁺; however,electronegative fluorine cannot be readily eliminated.Which of the following explains how enzyme inhibitors be fashioned to overcome this?
A)by replacing H with F-F at positions where catalysis involves H removal as H⁺
B)by replacing H with F- at positions where catalysis involves H removal as H⁺
C)by replacing H with F+ at positions where catalysis involves H removal as H⁺
D)by replacing H with F at positions where catalysis involves H removal as H⁺

Question

Quizplus · Accepted Answer

Hydrogen is replaced with fluorine at positions where catalysis involves H removal as H⁺ in order to overcome the difficulty in abstracting hydrogen from substrates containing electronegative fluorine.

Hydrogen Is Often Abstracted from Substrates as H⁺; However,electronegative Fluorine