In mammals,CPS-II is the regulated step in pyrimidine biosynthesis.Which of the following steps in pyrimidine biosynthesis is regulated in bacteria?
A)dihydroorotase
B)aspartate transcarbamoylase (ATCase)
C)OMP decarboxylase
D)dihydroorotate dehydrogenase

Question

Quizplus · Accepted Answer

In bacteria, the regulated step in pyrimidine biosynthesis is the first step, which is the conversion of carbamoyl phosphate and L-aspartate to N-carbamoyl-L-aspartate catalyzed by aspartate transcarbamoylase (ATCase). This step is regulated by feedback inhibition from the end product, cytidine triphosphate (CTP).

In Mammals,CPS-II Is the Regulated Step in Pyrimidine Biosynthesis