Which of the following is NOT a component of the basic rule of macromolecular recognition?
A) Protein recognizes nucleotide sequences by atomic contacts with bases and sugar-phosphate backbone,usually in the major groove.
B) Protein contacts involve H-bonds and salt bridges with electronegative oxygens of the phosphodiester linkages.
C) Proteins present a 3-dimensional shape or contour,structurally and chemically complementary to the surface of the DNA sequence.
D) Numerous hydrophobic interactions underlie recognition and binding.
Correct Answer:
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