All of the Following Concerning the Blood-Brain Barrier (BBB) and the Passage

All of the following concerning the blood-brain barrier (BBB) and the passage of drugs from the systemic circulation to cerebrospinal fluid (CSF) is true EXCEPT?

A) Ionized drugs are likely to cross into the CSF than unionized drugs
B) The higher the lipid solubility ofa drug, the more likely it will cross into the CSF
C) Inflammation of the meninges improves the likelihood that drugs will cross the BBB as
D) P glycoprotein serves to pump back the drugs into the systemic circulation from endothelial cell linings of the BBB