The phosphorylated immuno-receptor tyrosine-based activation motifs (ITAMs) of the BCR serve as a docking site for what adaptor protein?
A) Syk
B) NFAT
C) ZAP-70
D) Src kinase

Question

Quizplus · Accepted Answer

The syk enzyme binds to the phosphorylated tyrosine residues of the BCR ITAMs, which had been phosphorylated by src kinase. The activated syk bound to the ITAMs can then phosphorylate downstream targets, thus amplifying the signal and altering transcription by activating transcription factors, including NFAT and AP-1. The corresponding adaptor protein in T cells is ZAP-70.

The Phosphorylated Immuno-Receptor Tyrosine-Based Activation Motifs (ITAMs) of the BCR